2-Acetamino-1,2-dideoxynojirimycin—lysine hybrids as hexosaminidase inhibitors
نویسندگان
چکیده
منابع مشابه
Stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc) and ureido-DNJNAc derivatives as new hexosaminidase inhibitors.
2-Acetamido-1,2-dideoxyiminosugars are selective and potent inhibitors of hexosaminidases and therefore show high therapeutic potential for the treatment of various diseases, including several lysosomal storage disorders. A stereoselective synthesis of 2-acetamido-1,2-dideoxynojirimycin (DNJNAc), the iminosugar analog of N-acetylglucosamine, with a high overall yield is here described. This nov...
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ژورنال
عنوان ژورنال: Tetrahedron: Asymmetry
سال: 2009
ISSN: 0957-4166
DOI: 10.1016/j.tetasy.2009.02.015